Modulen IBD

Nutrition & Health / Healthcare Nutrition / Specialist Feeds / Modulen IBD / Modulen IBD
Modulen IBD is a nutritionally complete whole protein feed, clinically proven to achieve remission in Crohn's disease.

Key Features:

  • ACBS approved as a sole source of nutrition during the active phase of Crohn's disease and nutritional support during the remission phase for malnourished patients with Crohn's disease.
  • Suitable for adults and children over 5 years. Use with caution from 1-5 years. Unsuitable for less than 1 year of age.
  • Available as a powder in a 400g tin, requiring reconstitution with sterile water.

  • Suitable as a neutral flavoured oral sip feed or for administration as a tube feed.

  • ACBS approved Nestlé Nutrition Flavour Mix may be used with Modulen to prevent taste fatigue.

  • Nutritional complete in 2000mls

  • Protein source is casein which is naturally rich in TGF-ß2, and known to have anti-inflammatory properties, promoting healing of the gut wall.

Nutritional profile:
  • 1kcal/ml.
  • 3.6g protein/100ml.
  • 25% of fat present as MCT.
  • Clinically nil lactose.
We have a leaflet available which gives advice on food reintroduction once remission has been achieved. Please contact us if you require copies.

Modulen IBD

Further information is available by clicking the list of links below:
 Dietary Information
  Modulen Flavour Mix
Gluten Free Yes Yes
Milk Free No Yes
Egg Free Yes Yes
Soya Free No Yes
Wheat Free Yes Yes
Nut Free Yes Yes
Fish Free Yes Yes
Vegetarian Yes Yes
Vegan No Yes
Kosher Not Certified Not Certified
Halaal Not Certified Not Certified
  Nestlé Nutrition Flavour Mix contain a source of phenylalanine
Nutritional Information
Typical Values  Unit  Per 100g  Per 100ml  Per 1000ml
Energy  kJ / kcals  2070 / 500 420 / 100 4200 / 1000
Protein g 18.0 3.6 36.0
Carbohydrate g 54.0 11.0 110.0
sugars g 20.9 4.3 42.8
lactose g <0.1 <0.02 0.2
Fat g 23.0 4.7 47.0
saturates g 13.0 2.7 27.0
essential fatty acids g 2.5 0.51 5.1
MCT g 6.0 1.2 12.0
Fibre g 0 0 0
Minerals and Trace Elements  
 Typical Values  Unit  Per 100g  Per 100ml  Per 2000ml
Sodium mg / mmol 170 / 7.3  35/ 1.5  350 / 15.1
Potassium mg / mmol 600 / 15.6 120/ 3.1 1200 / 31.2
Calcium mg / mmol 450 / 11.3 91/ 2.3 910/ 23.0
Phosphorus mg / mmol 300 / 9.6 61 /1.9 610 / 19.5
Magnesium mg / mmol 100 / 4.1 20 /0.82 200 / 8.2
Chloride mg / mmol 370 / 10.4 75 /2.1 750 / 21
Iron mg 5.4 1.1 11.0
Zinc mg 4.7 0.96 9.6
Copper mg 0.5 0.1 1.0
Manganese mg 1.0 0.2 2.0
Fluoride mcg <0.0010 <0.00020 <0.002
Chromium mcg 25.0 5.1 51.0
Molybdenum mcg 37.0 7.5 75.0
Selenium mcg 17.0 3.5 35.0
Iodine mcg 49.0 10.0 100.0
Vitamins  
 Typical Values  Unit  Per 100g  Per 100ml  Per 2000ml
Vitamin A mcg RE 410.0 84.0 840.0
Vitamin D mcg 4.9 1.0 10.0
Vitamin E mg α TE 6.5 1.3 13.0
Vitamin K mcg 27.0 5.5 55.0
Vitamin C mg 47.0 9.7 97.0
Thiamin mg 0.6 0.1 1.2
Riboflavin mg 0.6 0.1 1.3
Pantothenic Acid mg 2.4 0.5 5.0
Vitamin B6 mg 0.8 0.2 1.7
Niacin mg / NE 5.8 / 9.8 1.2 / 2.0 20
Vitamin B 12 mcg 1.6 0.3 3.2
Folic acid mcg 120.0 24.0 240
Biotin mcg 16.0 3.2 32
Choline mcg 35.0 7.2 72
Inositol mcg 20.0 4.1 41
Water content % 85
Osmolarity (mOsm/l) 315
Osmolality (mOsm/kg) 370
Ingredients
Glucose syrup, casein, sucrose, milk fat, medium chain triglycerides, corn oil, emulsifier: soy lecithin, potassium citrate, calcium phosphate, sodium citrate, calcium carbonate, magnesium chloride, acidity regulator: potassium hydroxide, potassium chloride, vitamins (C, E, niacin, pantothenic acid, B6, B1, A, riboflavin, D, folic acid, K, biotin, B12), choline bitartarate, ferrous sulphate, zinc sulphate, magnesium oxide, manganese sulphate, copper sulphate, sodium molybdate, potassium iodide, chromium chloride, sodium selenite
Preparation Table
The recommended volume of Modulen IBD should be advised by a Dietitian.
  • Before preparation wash hands thoroughly.
  • Ensure all equipment and the preparation area are clean.
  • Measure the desired amount of powder using the scoop in the can.

(One level scoop is equivalent to approximately 8.2g and 41kcal).

Refer to the mixing table below:
 Volume of water  Modulen IBD  Total Volume of Feed  Calories provided
 200ml  6 scoops  250ml  250kcal
 420ml  12 scoops  500ml  500kcal
 850ml  24 scoops  1000ml  1000kcal
1740ml 1 can 2000ml 2000kcal
 
  •  Use cooled previously boiled water or sterile water.
  • Add the powder to the water and stir with a fork or a whisk.
  • Cover and refrigerate.
  • Mix well before serving.
  • Refrigerated product can be kept for 12 hours, non-chilled product can be kept for 4 hours only
  • (4 hours is also the recommended hanging time for Modulen IBD when used for tube feeding).
  • Discard product after these times
Handy Hints
  • On starting Modulen IBD, build up to your recommended volume over 2 to 3 days (discuss this with your Dietitian and ensure that you have adequate fluid whilst you are building up your total fluid volume). It does not need to be diluted further.
  • A Modulen IBD shaker is available to mix single 250ml drinks
  • Modulen IBD can be kept chilled in a flask for work or school
  • Using a straw can make it easier to take
  • In cold weather try warming the feed gently, to make a warm drink (do not boil though as this can alter
    the nutritional content).
  • In hot weather, try freezing it and making into ice-lollies
  • Brush your teeth more often to keep your mouth fresh
  • Include extra water to drink in your daily routine, especially in the summer months
Product Clinical Support
Latest papers: A Novel Approach to a Patient with Crohn's Disease and a High Stoma Output:
A missed Opportunity
Scand J Gastroenteral 2004; 39: 398 - 400
S. Jones, H. Shannon, E. Srivastava & N Haboubi
Mucosal Healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in Paediatric Crohn's Disease
Aliment Pharmacol Ther 2000 14 281-289
JME Fell, A Hollis, P Kitching, M Paintain, F Arnaud -Battandier, TT MacDonald, JA Walker Smith Bioactive molecules in milk and their role in health and disease: The role of transforming growth factor beta 2
Immunology and Cell Biology 2000 74-70
A Donnet-Hughes, N Duc, P Seaant, VK Vidal, EJ Schiffrin Polymeric nutrition as the primary therapy in children with small bowel Crohn's Disease
Aliment Pharmacol Ther 1994 8 609-615
RM Beattie, EJ Schiffrin, A Donnet Hughes, AC Huggett, P Domizio, TT Macdonald, JA Walker Smith   More support papers: Resolution of Mucosal inflammation and fall in Il-1b and interferon g mRNA in active Crohn's disease in response to polymeric diet (CT3211)
Royal College of Paediatrics and Child Health Annual Meeting 1998: vol 2
JME Fell, A Hollis, P Kitching, M Paintain, F Arnaud -Battandier, TT MacDonald, JA Walker Smith Normalisation of mucosal cytokine mRNA changing Th1/Th2 balance in association with clinical improvement in children with Crohn's Disease treated with polymeric diet CT3211
30th Annual ESPGAN meeting 1997
JME Fell, A Hollis, P Kitching, M Paintain, F Arnaud -Battandier, TT MacDonald, JA Walker Smith Resolution of Mucosal inflammation and fall in Il-1b mRNA in active Crohn's disease in response to polymeric diet (CT3211)
30th Annual ESPGAN meeting 1997
JME Fell, A Hollis, P Kitching, M Paintain, F Arnaud -Battandier, TT MacDonald, JA Walker Smith Responsiveness of IGF-1 and IGFBP-3 to therapeutic intervention in children and adolescents with Crohn's disease
Clinical Endocrinology 1998 49 483-489
RM Beattie, C Camacho-Hubner, S Wacharasindhu, AM Cotterill, JA walker Smith, MO Savage For further information, go to : www.modulenibd.com
Commonly Asked Questions
Is TGF-ß2 found in other milk products and what are its benefits?
TGF-ß2 is naturally present in human and bovine milk. Modulen IBD provides a concentrated form of TGF-ß2 above the levels naturally found in milk. Other formulas will not contain this level because they may not be casein based, and heat treatment destroys TGF-ß2.

TGF-ß2 possesses an anti-inflammatory property, promotes growth and tissue repair, and hence promotes the healing of gut wall ulceration.
Is Modulen the same as AL110?
AL110 is an infant formula produced for infant requirements. Similar to Modulen IBD, the protein in AL110 is casein based and therefore a source of TGF-ß2. Modulen IBD is based on the same formula, but has additional energy, protein, vitamins and minerals, in line with the requirements of older children and adults. (NB Al110 is no longer available in the UK)
Why should Modulen IBD be used for eight weeks?
Modulen IBD should be used as a sole source of nutrition for eight weeks to allow time for the intestinal mucosa to heal and for the patient to achieve remission. Clinical evidence shows that the longer the patient allows healing to occur, the greater the period of remission.
The clinical evidence so far is from studies in children. What about adults?
Clinicians state that the efficacy of Modulen IBD in children with Crohn's disease can be applied to adults. Many Dietitians throughout the UK have used Modulen IBD successfully in adults. Please contact NCN for further information.
Why should sterile/cooled boiled water be used to mix Modulen IBD?
There are potential risks involved with bacterial contamination from tap water. During illness a person's immune system can be compromised. In view of this risk it is safer to use sterile water in the healthcare setting, and cooled boiled water at home.
Can food be eaten whilst taking Modulen IBD?
This depends on whether Modulen IBD is being taken as a sole source of nutrition for treatment of active Crohn's disease, or as a supplement during remission.
For treatment of active Crohn's disease, food should not be eaten to avoid any possible food intolerance, or irritation to the gut.

After the 8 week period, once full remission has been achieved, the food re-introduction programme can begin. This should be discussed with a Dietitian and practices may differ between different hospitals. Modulen IBD can be continued through this stage as a nutritional supplement and reduced as food intake increases.

For patients who are in remission, requiring nutritional support, Modulen IBD can be taken in addition to food.
Why is Modulen IBD not available as a liquid?
The heat treatment required to make the liquid would destroy the TGF-ß2.
What is the GM position on Modulen IBD?
Modulen IBD does not contain DNA/protein from GM soya and/or maize
© Nestlé UK Ltd 2008
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